Profile of Gene Expression in Rat Mandibular Distraction Osteogenesis: A Thesis Submitted in Partial Fulfillment ... for the Degree of Master of Science in Orthodontics ...University of Michigan, 2002 - 198 sayfa |
İçindekiler
Antagonists in Rat Mandibular Distraction Osteogenesis | 23 |
Materials and Methods | 31 |
Results | 36 |
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activity acutely lengthened mandibles animals application areas arrow BMP antagonists BMP expression bone formation bone morphogenetic proteins bone sialoprotein bony cell culture cells central fibrous zone chondrocytes collagen consolidation day craniofacial critical Data not shown day 9 decreased detected distraction day distraction osteogenesis early effect et al expression of BMP extending bone factor fibroblasts finding formed fracture healing function gene expression gradually distracted mandibles hybridization important increase indicates induce initial insert involved known late lateral levels localized mandibular distraction osteogenesis mature mechanical molecules negative Noggin and Gremlin normal Northern blot analysis observed osteoblasts osteocalcin osteocalcin expression osteogenic osteoinductive osteotomized edges osteotomy pattern periphery points present study Reddi regulators remodeling response revealed role Runx 2 expression seen sham-operated signals similar specific successful suggest Surg tissue traction utilizing various Wozney zone of extending